Anti-Synaptopodin SYNPO Antibody

Product Name

Anti-Synaptopodin SYNPO Antibody

View all Synaptopodin Antibodies

SKU/Catalog Number

A03154

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Synaptopodin SYNPO Antibody (Catalog # A03154). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

SYNPO antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-Synaptopodin SYNPO Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03154)

Host

Rabbit

Contents

SYNPO Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Clone Number

Clone: SK7

Isotype

IgG

Immunogen

SYNPO antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human SYNPO. The immunogen is located within the last 50 amino acids of SYNPO.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

At least three isoforms of SYNPO are known to exist; this antibody will detect all three isoforms. SYNPO antibody is predicted to not cross-react with other SYNPO family member proteins.

Reactive Species

A03154 is reactive to SYNPO in Human, Mouse, Rat

Applications

A03154 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee

Observed Molecular Weight

68 kDa

Calculated molecular weight

99.463kDa

Background of Synaptopodin

SYNPO, also known as synaptopodin, is an actin-associated protein in telencephalic dendrites and renal podocytes. SYNPO is tightly associated with the dendritic spine apparatus, and mice lacking the SYNPO gene lack the apparatus. These SYNPO-null mice also demonstrate an impaired ability to express long-term potentiation as well as deficits in spatial memory tasks, indicating that SYNPO is involved in the regulation of synaptic plasticity. Recent studies suggest that SYNPO is linked to neuronal calcium stores and plays a role in the calcium store-associated ability of neurons to undergo long-term plasticity.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

SYNPO antibody can be used for detection of SYNPO by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human and mouse samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

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Western blot analysis of SYNPO in rat brain tissue lysate with SYNPO antibody at (A) 1 and (B) 2 μg/mL.

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Immunohistochemistry of SYNPO in human brain tissue with SYNPO antibody at 2.5 μg/mL.

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Immunofluorescence of SYNPO in human brain tissue with SYNPO antibody at 20 μg/mL.

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Immunofluorescence of SYNPO in mouse brain tissue with SYNPO antibody at 20 μg/mL.

Red: SYNPO Antibody (A03154)
Blue: DAPI staining

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Immunohistochemistry of SYNPO in mouse brain tissue with SYNPO antibody at 5 μg/mL.

Gene/Protein Information For SYNPO (Source: Uniprot.org, NCBI)

Alternative Names

KIAA1029; Synaptopodin; SYNPO SYNPO synaptopodin synaptopodin

For more info on SYNPO, check out the SYNPO Infographic

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In this infographic, you will see the following information for SYNPO: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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